Structural investigation of 2‐naphthyl phenyl ether inhibitors bound to WT and Y181C reverse transcriptase highlights key features of the NNRTI binding site

Human immunodeficiency virus (HIV)‐1 remains as a global health issue that is primarily treated with highly active antiretroviral therapy, a combination of drugs that target the viral life cycle. One class of these drugs are non‐nucleoside reverse transcriptase inhibitors (NNRTIs) that target the vi...

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Vydáno v:Protein Sci
Hlavní autoři: Duong, Vincent N., Ippolito, Joseph A., Chan, Albert H., Lee, Won‐Gil, Spasov, Krasimir A., Jorgensen, William L., Anderson, Karen S.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley & Sons, Inc. 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7454559/
https://ncbi.nlm.nih.gov/pubmed/32643196
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.3910
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