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Characterising covalent warhead reactivity
Many drugs currently used are covalent inhibitors and irreversibly inhibit their targets. Most of these were discovered through serendipity. Covalent inhibitions can have many advantages from a pharmacokinetic perspective. However, until recently most organisations have shied away from covalent comp...
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| Publicado no: | Bioorg Med Chem |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6538824/ https://ncbi.nlm.nih.gov/pubmed/30975501 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.04.002 |
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