Investigation of Covalent Warheads in the Design of 2-Aminopyrimidine-based FGFR4 Inhibitors

[Image: see text] Covalent kinase inhibitors are rapidly emerging as a class of therapeutics with clinical benefits. Herein we report a series of selective 2-aminopyrimidine-based fibroblast growth factor receptor 4 (FGFR4) inhibitors exploring different types of cysteine-targeting warheads. The str...

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Pubblicato in:ACS Med Chem Lett
Autori principali: Deng, Wuqing, Chen, Xiaojuan, Jiang, Kaili, Song, Xiaojuan, Huang, Minhao, Tu, Zheng-Chao, Zhang, Zhang, Lin, Xiaojing, Ortega, Raquel, Patterson, Adam V., Smaill, Jeff B., Ding, Ke, Chen, Suming, Chen, Yongheng, Lu, Xiaoyun
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Chemical Society 2021
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8040253/
https://ncbi.nlm.nih.gov/pubmed/33859803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.1c00052
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