2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors

[Image: see text] A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds 2n tightly bound FGFR4 with a K(d) value of 3.3 nM and potently inhibited its enzymatic activity with an IC(50) value of 2.6 nM, but com...

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Detalhes bibliográficos
Publicado no:ACS Med Chem Lett
Main Authors: Mo, Cheng, Zhang, Zhang, Guise, Christopher P., Li, Xueqiang, Luo, Jinfeng, Tu, Zhengchao, Xu, Yong, Patterson, Adam V., Smaill, Jeff B., Ren, Xiaomei, Lu, Xiaoyun, Ding, Ke
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2017
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5430393/
https://ncbi.nlm.nih.gov/pubmed/28523108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00091
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