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2-Aminopyrimidine Derivatives as New Selective Fibroblast Growth Factor Receptor 4 (FGFR4) Inhibitors
[Image: see text] A series of 2-aminopyrimidine derivatives were designed and synthesized as highly selective FGFR4 inhibitors. One of the most promising compounds 2n tightly bound FGFR4 with a K(d) value of 3.3 nM and potently inhibited its enzymatic activity with an IC(50) value of 2.6 nM, but com...
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| Pubblicato in: | ACS Med Chem Lett |
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| Autori principali: | , , , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
American Chemical
Society
2017
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| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5430393/ https://ncbi.nlm.nih.gov/pubmed/28523108 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.7b00091 |
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