N-(3-Ethynyl-2,4-difluorophenyl)sulfonamide Derivatives as Selective Raf Inhibitors

[Image: see text] A series of N-(3-ethynyl-2,4-difluorophenyl)sulfonamides were identified as new selective Raf inhibitors. The compounds potently inhibit B-Raf(V600E) with low nanomolar IC(50) values and exhibit excellent target specificity in a selectivity profiling investigation against 468 kinas...

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Publicado en:ACS Med Chem Lett
Main Authors: Li, Yingjun, Cheng, Huimin, Zhang, Zhang, Zhuang, Xiaoxi, Luo, Jinfeng, Long, Huoyou, Zhou, Yang, Xu, Yong, Taghipouran, Rana, Li, Dan, Patterson, Adam, Smaill, Jeff, Tu, Zhengchao, Wu, Donghai, Ren, Xiaomei, Ding, Ke
Formato: Artigo
Idioma:Inglês
Publicado: American Chemical Society 2015
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4434482/
https://ncbi.nlm.nih.gov/pubmed/26005530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.5b00039
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