The role of glycosylation in the N-terminus of the hemagglutinin of a unique H4N2 with a natural polybasic cleavage site in virus fitness in vitro and in vivo

To date, only low pathogenic (LP) H5 and H7 avian influenza viruses (AIV) have been observed to naturally shift to a highly pathogenic (HP) phenotype after mutation of the monobasic hemagglutinin (HA) cleavage site (HACS) to polybasic motifs. The LPAIV monobasic HACS is activated by tissue-restricte...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Virulence
Autori principali: Gischke, Marcel, Bagato, Ola, Breithaupt, Angele, Scheibner, David, Blaurock, Claudia, Vallbracht, Melina, Karger, Axel, Crossley, Beate, Veits, Jutta, Böttcher-Friebertshäuser, Eva, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Taylor & Francis 2021
Soggetti:
Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7872060/
https://ncbi.nlm.nih.gov/pubmed/33538209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/21505594.2021.1881344
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