Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks

Avian influenza viruses (AIV) are classified into 16 hemagglutinin (HA; H1-H16) and 9 neuraminidase (NA; N1-N9) subtypes. All AIV are low pathogenic (LP) in birds, but subtypes H5 and H7 AIV can evolve into highly pathogenic (HP) forms. In the last two decades evolution of HPAIV H7 from LPAIV has be...

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Publicado no:Sci Rep
Main Authors: Scheibner, David, Ulrich, Reiner, Fatola, Olanrewaju I., Graaf, Annika, Gischke, Marcel, Salaheldin, Ahmed H., Harder, Timm C., Veits, Jutta, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689016/
https://ncbi.nlm.nih.gov/pubmed/31399610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47938-3
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