Insertion of Basic Amino Acids in the Hemagglutinin Cleavage Site of H4N2 Avian Influenza Virus (AIV)—Reduced Virus Fitness in Chickens is Restored by Reassortment with Highly Pathogenic H5N1 AIV

Highly pathogenic (HP) avian influenza viruses (AIVs) are naturally restricted to H5 and H7 subtypes with a polybasic cleavage site (CS) in hemagglutinin (HA) and any AIV with an intravenous pathogenicity index (IVPI) ≥ 1.2. Although only a few non-H5/H7 viruses fulfill the criteria of HPAIV; it rem...

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Publicat a:Int J Mol Sci
Autors principals: Gischke, Marcel, Ulrich, Reiner, I. Fatola, Olanrewaju, Scheibner, David, Salaheldin, Ahmed H., Crossley, Beate, Böttcher-Friebertshäuser, Eva, Veits, Jutta, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Format: Artigo
Idioma:Inglês
Publicat: MDPI 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7178042/
https://ncbi.nlm.nih.gov/pubmed/32231159
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms21072353
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