Non-basic amino acids in the hemagglutinin proteolytic cleavage site of a European H9N2 avian influenza virus modulate virulence in turkeys

H9N2 avian influenza virus (AIV) is the most widespread low pathogenic (LP) AIV in poultry and poses a serious zoonotic risk. Vaccination is used extensively to mitigate the economic impact of the virus. However, mutations were acquired after long-term circulation of H9N2 virus in poultry, particula...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Blaurock, Claudia, Scheibner, David, Landmann, Maria, Vallbracht, Melina, Ulrich, Reiner, Böttcher-Friebertshäuser, Eva, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7718272/
https://ncbi.nlm.nih.gov/pubmed/33277593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-78210-8
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