Variable impact of the hemagglutinin polybasic cleavage site on virulence and pathogenesis of avian influenza H7N7 virus in chickens, turkeys and ducks

Avian influenza viruses (AIV) are classified into 16 hemagglutinin (HA; H1-H16) and 9 neuraminidase (NA; N1-N9) subtypes. All AIV are low pathogenic (LP) in birds, but subtypes H5 and H7 AIV can evolve into highly pathogenic (HP) forms. In the last two decades evolution of HPAIV H7 from LPAIV has be...

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Vydáno v:Sci Rep
Hlavní autoři: Scheibner, David, Ulrich, Reiner, Fatola, Olanrewaju I., Graaf, Annika, Gischke, Marcel, Salaheldin, Ahmed H., Harder, Timm C., Veits, Jutta, Mettenleiter, Thomas C., Abdelwhab, Elsayed M.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6689016/
https://ncbi.nlm.nih.gov/pubmed/31399610
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-47938-3
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