Replication-independent instability of Friedreich’s ataxia GAA repeats during chronological aging

Nearly 50 hereditary diseases result from the inheritance of abnormally long repetitive DNA microsatellites. While it was originally believed that the size of inherited repeats is the key factor in disease development, it has become clear that somatic instability of these repeats throughout an indiv...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Neil, Alexander J., Hisey, Julia A., Quasem, Ishtiaque, McGinty, Ryan J., Hitczenko, Marcin, Khristich, Alexandra N., Mirkin, Sergei M.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2021
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7865128/
https://ncbi.nlm.nih.gov/pubmed/33495349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2013080118
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