Replication-mediated instability of the GAA triplet repeat mutation in Friedreich ataxia

Friedreich ataxia is caused by the expansion of a polymorphic and unstable GAA triplet repeat in the FRDA gene, but the mechanisms for its instability are poorly understood. Replication of (GAA•TTC)(n) sequences (9–105 triplets) in plasmids propagated in Escherichia coli displayed length- and orient...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Pollard, Laura M., Sharma, Rajesh, Gómez, Mariluz, Shah, Sonali, Delatycki, Martin B., Pianese, Luigi, Monticelli, Antonella, Keats, Bronya J.B., Bidichandani, Sanjay I.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Oxford University Press 2004
Gaiak:
Articles
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC528813/
https://ncbi.nlm.nih.gov/pubmed/15534367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh933
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