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Replication-mediated instability of the GAA triplet repeat mutation in Friedreich ataxia
Friedreich ataxia is caused by the expansion of a polymorphic and unstable GAA triplet repeat in the FRDA gene, but the mechanisms for its instability are poorly understood. Replication of (GAA•TTC)(n) sequences (9–105 triplets) in plasmids propagated in Escherichia coli displayed length- and orient...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Oxford University Press
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528813/ https://ncbi.nlm.nih.gov/pubmed/15534367 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh933 |
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