Epigenetic Heterogeneity in Friedreich Ataxia Underlies Variable FXN Reactivation
Friedreich ataxia (FRDA) is typically caused by homozygosity for an expanded GAA triplet-repeat in intron 1 of the FXN gene. The expanded repeat induces repressive histone changes and DNA hypermethylation, which result in epigenetic silencing and FXN transcriptional deficiency. A class I histone dea...
Uloženo v:
| Hlavní autoři: | , , , , |
|---|---|
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Frontiers Media S.A.
2021-11-01
|
| Edice: | Frontiers in Neuroscience |
| Témata: | |
| On-line přístup: | https://www.frontiersin.org/articles/10.3389/fnins.2021.752921/full |
| Tagy: |
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|