Epigenetic Heterogeneity in Friedreich Ataxia Underlies Variable FXN Reactivation
Friedreich ataxia (FRDA) is typically caused by homozygosity for an expanded GAA triplet-repeat in intron 1 of the FXN gene. The expanded repeat induces repressive histone changes and DNA hypermethylation, which result in epigenetic silencing and FXN transcriptional deficiency. A class I histone dea...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Frontiers Media S.A.
2021-11-01
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| Serie: | Frontiers in Neuroscience |
| Soggetti: | |
| Accesso online: | https://www.frontiersin.org/articles/10.3389/fnins.2021.752921/full |
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