Replication-mediated instability of the GAA triplet repeat mutation in Friedreich ataxia

Friedreich ataxia is caused by the expansion of a polymorphic and unstable GAA triplet repeat in the FRDA gene, but the mechanisms for its instability are poorly understood. Replication of (GAA•TTC)(n) sequences (9–105 triplets) in plasmids propagated in Escherichia coli displayed length- and orient...

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Main Authors: Pollard, Laura M., Sharma, Rajesh, Gómez, Mariluz, Shah, Sonali, Delatycki, Martin B., Pianese, Luigi, Monticelli, Antonella, Keats, Bronya J.B., Bidichandani, Sanjay I.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC528813/
https://ncbi.nlm.nih.gov/pubmed/15534367
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh933
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