The ubiquitin ligase RFWD3 is required for translesion DNA synthesis

Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis involves either translesion DNA synthesis (TLS) or template...

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Publicado en:Mol Cell
Main Authors: Gallina, Irene, Hendriks, Ivo A., Hoffmann, Saskia, Larsen, Nicolai B., Johansen, Joachim, Colding-Christensen, Camilla S., Schubert, Lisa, Sellés-Baiget, Selene, Fábián, Zita, Kühbacher, Ulrike, Gao, Alan O., Räschle, Markus, Rasmussen, Simon, Nielsen, Michael L., Mailand, Niels, Duxin, Julien P.
Formato: Artigo
Idioma:Inglês
Publicado: Cell Press 2021
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864614/
https://ncbi.nlm.nih.gov/pubmed/33321094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.029
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