The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner

RFWD3 is an E3 ubiquitin ligase that plays important roles in DNA damage response and DNA replication. We have previously demonstrated that the stabilization of RFWD3 by PCNA at the replication fork enables ubiquitination of the single-stranded binding protein, RPA and its subsequent degradation for...

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Udgivet i:Cell Cycle
Main Authors: Hsu, Rosaline Y.C., Giri, Sumanprava, Wang, Yating, Lin, Yo-Chuen, Liu, Dazhen, Wopat, Susan, Chakraborty, Arindam, Prasanth, Kannanganattu V., Prasanth, Supriya G.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7714534/
https://ncbi.nlm.nih.gov/pubmed/33044890
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2020.1829823
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