PCNA-mediated stabilization of E3 ligase RFWD3 at the replication fork is essential for DNA replication

RING finger and WD repeat domain-containing protein 3 (RFWD3) is an E3 ligase known to facilitate homologous recombination by removing replication protein A (RPA) and RAD51 from DNA damage sites. Further, RPA-mediated recruitment of RFWD3 to stalled replication forks is essential for interstrand cro...

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Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Lin, Yo-Chuen, Wang, Yating, Hsu, Rosaline, Giri, Sumanprava, Wopat, Susan, Arif, Mariam K., Chakraborty, Arindam, Prasanth, Kannanganattu V., Prasanth, Supriya G.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2018
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6310862/
https://ncbi.nlm.nih.gov/pubmed/30530694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1814521115
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