RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks

We have used quantitative proteomics to profile ubiquitination in the DNA damage response (DDR). We demonstrate that RPA, which functions as a protein scaffold in the replication stress response, is multiply ubiquitinated upon replication fork stalling. Ubiquitination of RPA occurs on chromatin, inv...

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Pubblicato in:Mol Cell
Autori principali: Elia, Andrew E.H., Wang, David C., Willis, Nicholas A., Boardman, Alexander P., Hajdu, Ildiko, Adeyemi, Richard O., Lowry, Elizabeth, Gygi, Steven P., Scully, Ralph, Elledge, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609029/
https://ncbi.nlm.nih.gov/pubmed/26474068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.011
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