RFWD3-Dependent Ubiquitination of RPA Regulates Repair at Stalled Replication Forks

We have used quantitative proteomics to profile ubiquitination in the DNA damage response (DDR). We demonstrate that RPA, which functions as a protein scaffold in the replication stress response, is multiply ubiquitinated upon replication fork stalling. Ubiquitination of RPA occurs on chromatin, inv...

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Detalhes bibliográficos
Publicado no:Mol Cell
Main Authors: Elia, Andrew E.H., Wang, David C., Willis, Nicholas A., Boardman, Alexander P., Hajdu, Ildiko, Adeyemi, Richard O., Lowry, Elizabeth, Gygi, Steven P., Scully, Ralph, Elledge, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4609029/
https://ncbi.nlm.nih.gov/pubmed/26474068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.09.011
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