Phosphorylated RPA recruits PALB2 to stalled DNA replication forks to facilitate fork recovery

Phosphorylation of replication protein A (RPA) by Cdk2 and the checkpoint kinase ATR (ATM and Rad3 related) during replication fork stalling stabilizes the replisome, but how these modifications safeguard the fork is not understood. To address this question, we used single-molecule fiber analysis in...

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Detalhes bibliográficos
Main Authors: Murphy, Anar K., Fitzgerald, Michael, Ro, Teresa, Kim, Jee Hyun, Rabinowitsch, Ariana I., Chowdhury, Dipanjan, Schildkraut, Carl L., Borowiec, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2014
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137056/
https://ncbi.nlm.nih.gov/pubmed/25113031
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201404111
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