Dynamic Association of ORCA with Prereplicative Complex Components Regulates DNA Replication Initiation

In eukaryotes, initiation of DNA replication requires the assembly of a multiprotein prereplicative complex (pre-RC) at the origins. We recently reported that a WD repeat-containing protein, origin recognition complex (ORC)-associated (ORCA/LRWD1), plays a crucial role in stabilizing ORC to chromati...

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Main Authors: Shen, Zhen, Chakraborty, Arindam, Jain, Ankur, Giri, Sumanprava, Ha, Taekjip, Prasanth, Kannanganattu V., Prasanth, Supriya G.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434513/
https://ncbi.nlm.nih.gov/pubmed/22645314
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00362-12
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