The preRC protein ORCA organizes heterochromatin by assembling histone H3 lysine 9 methyltransferases on chromatin

Heterochromatic domains are enriched with repressive histone marks, including histone H3 lysine 9 methylation, written by lysine methyltransferases (KMTs). The pre-replication complex protein, origin recognition complex-associated (ORCA/LRWD1), preferentially localizes to heterochromatic regions in...

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Bibliographic Details
Published in:eLife
Main Authors: Giri, Sumanprava, Aggarwal, Vasudha, Pontis, Julien, Shen, Zhen, Chakraborty, Arindam, Khan, Abid, Mizzen, Craig, Prasanth, Kannanganattu V, Ait-Si-Ali, Slimane, Ha, Taekjip, Prasanth, Supriya G
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2015
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4442312/
https://ncbi.nlm.nih.gov/pubmed/25922909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06496
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