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The ubiquitin ligase RFWD3 is required for translesion DNA synthesis
Lesions on DNA uncouple DNA synthesis from the replisome, generating stretches of unreplicated single-stranded DNA (ssDNA) behind the replication fork. These ssDNA gaps need to be filled in to complete DNA duplication. Gap-filling synthesis involves either translesion DNA synthesis (TLS) or template...
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| Publicado en: | Mol Cell |
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| Autores principales: | , , , , , , , , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Cell Press
2021
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7864614/ https://ncbi.nlm.nih.gov/pubmed/33321094 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2020.11.029 |
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