E3 ligase RFWD3 is a novel modulator of stalled fork stability in BRCA2-deficient cells

BRCA1/2 help maintain genomic integrity by stabilizing stalled forks. Here, we identify the E3 ligase RFWD3 as an essential modulator of stalled fork stability in BRCA2-deficient cells and show that codepletion of RFWD3 rescues fork degradation, collapse, and cell sensitivity upon replication stress...

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Detalhes bibliográficos
Publicado no:J Cell Biol
Main Authors: Duan, Haohui, Mansour, Sarah, Reed, Rachel, Gillis, Margaret K., Parent, Benjamin, Liu, Ben, Sztupinszki, Zsofia, Birkbak, Nicolai, Szallasi, Zoltan, Elia, Andrew E.H., Garber, Judy E., Pathania, Shailja
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7265328/
https://ncbi.nlm.nih.gov/pubmed/32391871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201908192
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