CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cancer Immunol Res
Egile Nagusiak: Boucher, Justin C., Li, Gongbo, Kotani, Hiroshi, Cabral, Maria L., Morrissey, Dylan, Lee, Sae Bom, Spitler, Kristen, Beatty, Nolan J., Cervantes, Estelle V., Shrestha, Bishwas, Yu, Bin, Kazi, Aslamuzzaman, Wang, Xuefeng, Sebti, Said M., Davila, Marco L.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864379/
https://ncbi.nlm.nih.gov/pubmed/33188139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0253
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