CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Cancer Immunol Res
Main Authors: Boucher, Justin C., Li, Gongbo, Kotani, Hiroshi, Cabral, Maria L., Morrissey, Dylan, Lee, Sae Bom, Spitler, Kristen, Beatty, Nolan J., Cervantes, Estelle V., Shrestha, Bishwas, Yu, Bin, Kazi, Aslamuzzaman, Wang, Xuefeng, Sebti, Said M., Davila, Marco L.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864379/
https://ncbi.nlm.nih.gov/pubmed/33188139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0253
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki