CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion...

詳細記述

保存先:
書誌詳細
出版年:Cancer Immunol Res
主要な著者: Boucher, Justin C., Li, Gongbo, Kotani, Hiroshi, Cabral, Maria L., Morrissey, Dylan, Lee, Sae Bom, Spitler, Kristen, Beatty, Nolan J., Cervantes, Estelle V., Shrestha, Bishwas, Yu, Bin, Kazi, Aslamuzzaman, Wang, Xuefeng, Sebti, Said M., Davila, Marco L.
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864379/
https://ncbi.nlm.nih.gov/pubmed/33188139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0253
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