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Selecting costimulatory domains for chimeric antigen receptors: functional and clinical considerations
Costimulatory signals are required to achieve robust chimeric antigen receptor (CAR) T cell expansion, function, persistence and antitumor activity. These can be provided by incorporating intracellular signalling domains from one or more T cell costimulatory molecules, such as CD28 or 4‐1BB, into th...
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| Publicado no: | Clin Transl Immunology |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6511336/ https://ncbi.nlm.nih.gov/pubmed/31110702 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cti2.1049 |
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