CD28 Costimulatory Domain–Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function

An obstacle to the development of chimeric antigen receptor (CAR) T cells is the limited understanding of CAR T-cell biology and the mechanisms behind their antitumor activity. We and others have shown that CARs with a CD28 costimulatory domain drive high T-cell activation, which leads to exhaustion...

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Bibliografiske detaljer
Udgivet i:Cancer Immunol Res
Main Authors: Boucher, Justin C., Li, Gongbo, Kotani, Hiroshi, Cabral, Maria L., Morrissey, Dylan, Lee, Sae Bom, Spitler, Kristen, Beatty, Nolan J., Cervantes, Estelle V., Shrestha, Bishwas, Yu, Bin, Kazi, Aslamuzzaman, Wang, Xuefeng, Sebti, Said M., Davila, Marco L.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7864379/
https://ncbi.nlm.nih.gov/pubmed/33188139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2326-6066.CIR-20-0253
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