Complement activity is regulated in C3 glomerulopathy by IgG–factor H fusion proteins with and without properdin targeting domains

C3 glomerulopathy is characterized by accumulation of complement C3 within glomeruli. Causes include, but are not limited to, abnormalities in factor H, the major negative regulator of the complement alternative pathway. Factor H-deficient (Cfh(-/-)) mice develop C3 glomerulopathy together with a re...

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Detalhes bibliográficos
Publicado no:Kidney Int
Main Authors: Gilmore, Alyssa C., Zhang, Yuchun, Cook, H. Terence, Lavin, Deborah P., Katti, Suresh, Wang, Yi, Johnson, Krista K., Kim, SungKwon, Pickering, Matthew C.
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2021
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7863913/
https://ncbi.nlm.nih.gov/pubmed/33129896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.kint.2020.09.028
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