Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency

Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator. CFH-deficient mice (CFH(−/−)) develop uncontrolled C3 activation and spontaneous renal disease characterized by accumulation of C3 along the glomerular basement m...

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Detalhes bibliográficos
Main Authors: Ruseva, Marieta M., Vernon, Katherine A., Lesher, Allison M., Schwaeble, Wilhelm J., Ali, Youssif M., Botto, Marina, Cook, Terence, Song, Wenchao, Stover, Cordula M., Pickering, Matthew Caleb
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2012
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3537217/
https://ncbi.nlm.nih.gov/pubmed/23184055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012060571
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