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Loss of Properdin Exacerbates C3 Glomerulopathy Resulting from Factor H Deficiency
Complement factor H (CFH) is a negative regulator of the alternative pathway of complement, and properdin is the sole positive regulator. CFH-deficient mice (CFH(−/−)) develop uncontrolled C3 activation and spontaneous renal disease characterized by accumulation of C3 along the glomerular basement m...
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| 主要な著者: | , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society of Nephrology
2012
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3537217/ https://ncbi.nlm.nih.gov/pubmed/23184055 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2012060571 |
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