Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis

ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1) play a vital role in promoting cholesterol efflux. Although, the dysregulation of these transporters was attributed as one of the mechanisms of atherogenesis, what renders their dysfunction is not well explored. Previously, we have reported...

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Udgivet i:Cell Death Differ
Main Authors: Boro, Monoranjan, Govatati, Suresh, Kumar, Raj, Singh, Nikhlesh K., Pichavaram, Prahalathan, Traylor, James G., Orr, A. Wayne, Rao, Gadiparthi N.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862243/
https://ncbi.nlm.nih.gov/pubmed/32968199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00623-9
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