Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3–mediated degradation of the ABCA1 transporter

Although signaling of thrombin via its receptor protease-activated receptor 1 (Par1) is known to occur in atherothrombosis, its link to the actual pathogenesis of this condition is less clear. To better understand the role of thrombin–Par1 signaling in atherosclerosis, here we have studied their eff...

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Bibliographische Detailangaben
Veröffentlicht in:J Biol Chem
Hauptverfasser: Raghavan, Somasundaram, Singh, Nikhlesh K., Mani, Arul M., Rao, Gadiparthi N.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2018
Schlagworte:
Signal Transduction
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6036195/
https://ncbi.nlm.nih.gov/pubmed/29777060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003491
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