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Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3–mediated degradation of the ABCA1 transporter
Although signaling of thrombin via its receptor protease-activated receptor 1 (Par1) is known to occur in atherothrombosis, its link to the actual pathogenesis of this condition is less clear. To better understand the role of thrombin–Par1 signaling in atherosclerosis, here we have studied their eff...
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| Veröffentlicht in: | J Biol Chem |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6036195/ https://ncbi.nlm.nih.gov/pubmed/29777060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.003491 |
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