Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis

ATP-binding cassette transporters A1 (ABCA1) and G1 (ABCG1) play a vital role in promoting cholesterol efflux. Although, the dysregulation of these transporters was attributed as one of the mechanisms of atherogenesis, what renders their dysfunction is not well explored. Previously, we have reported...

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Foilsithe in:Cell Death Differ
Main Authors: Boro, Monoranjan, Govatati, Suresh, Kumar, Raj, Singh, Nikhlesh K., Pichavaram, Prahalathan, Traylor, James G., Orr, A. Wayne, Rao, Gadiparthi N.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7862243/
https://ncbi.nlm.nih.gov/pubmed/32968199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-020-00623-9
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