X-linked cellular mosaicism underlies age-dependent occurrence of seizure-like events in mouse models of CDKL5 deficiency disorder

CDKL5 deficiency disorder (CDD) is an infantile epileptic encephalopathy presenting with early-onset seizures, intellectual disability, motor impairment, and autistic features. The disorder has been linked to mutations in the X-linked CDKL5, and mouse models of the disease recapitulate several aspec...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Neurobiol Dis
Prif Awduron: Terzic, Barbara, Cui, Yue, Edmondson, Andrew C., Tang, Sheng, Sarmiento, Nicolas, Zaitseva, Daria, Marsh, Eric D., Coulter, Douglas A., Zhou, Zhaolan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856307/
https://ncbi.nlm.nih.gov/pubmed/33197557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105176
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