Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome (RTT), autism spectrum disorders (ASDs), and early infantile epileptic encephalopathy. The biological function of CDKL5 and its role in the etio...

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Detalhes bibliográficos
Main Authors: Wang, I-Ting Judy, Allen, Megan, Goffin, Darren, Zhu, Xinjian, Fairless, Andrew H., Brodkin, Edward S., Siegel, Steve J., Marsh, Eric D., Blendy, Julie A., Zhou, Zhaolan
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535652/
https://ncbi.nlm.nih.gov/pubmed/23236174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216988110
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