Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome (RTT), autism spectrum disorders (ASDs), and early infantile epileptic encephalopathy. The biological function of CDKL5 and its role in the etio...

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Hlavní autoři: Wang, I-Ting Judy, Allen, Megan, Goffin, Darren, Zhu, Xinjian, Fairless, Andrew H., Brodkin, Edward S., Siegel, Steve J., Marsh, Eric D., Blendy, Julie A., Zhou, Zhaolan
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2012
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535652/
https://ncbi.nlm.nih.gov/pubmed/23236174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216988110
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