Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome (RTT), autism spectrum disorders (ASDs), and early infantile epileptic encephalopathy. The biological function of CDKL5 and its role in the etio...

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Bibliographische Detailangaben
Hauptverfasser: Wang, I-Ting Judy, Allen, Megan, Goffin, Darren, Zhu, Xinjian, Fairless, Andrew H., Brodkin, Edward S., Siegel, Steve J., Marsh, Eric D., Blendy, Julie A., Zhou, Zhaolan
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2012
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535652/
https://ncbi.nlm.nih.gov/pubmed/23236174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216988110
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