Altered NMDAR signaling underlies autistic-like features in mouse models of CDKL5 deficiency disorder

CDKL5 deficiency disorder (CDD) is characterized by epilepsy, intellectual disability, and autistic features, and CDKL5-deficient mice exhibit a constellation of behavioral phenotypes reminiscent of the human disorder. We previously found that CDKL5 dysfunction in forebrain glutamatergic neurons res...

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Udgivet i:Nat Commun
Main Authors: Tang, Sheng, Terzic, Barbara, Wang, I-Ting Judy, Sarmiento, Nicolas, Sizov, Katherine, Cui, Yue, Takano, Hajime, Marsh, Eric D., Zhou, Zhaolan, Coulter, Douglas A.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6572855/
https://ncbi.nlm.nih.gov/pubmed/31201320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10689-w
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