X-linked cellular mosaicism underlies age-dependent occurrence of seizure-like events in mouse models of CDKL5 deficiency disorder

CDKL5 deficiency disorder (CDD) is an infantile epileptic encephalopathy presenting with early-onset seizures, intellectual disability, motor impairment, and autistic features. The disorder has been linked to mutations in the X-linked CDKL5, and mouse models of the disease recapitulate several aspec...

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Publicado en:Neurobiol Dis
Main Authors: Terzic, Barbara, Cui, Yue, Edmondson, Andrew C., Tang, Sheng, Sarmiento, Nicolas, Zaitseva, Daria, Marsh, Eric D., Coulter, Douglas A., Zhou, Zhaolan
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7856307/
https://ncbi.nlm.nih.gov/pubmed/33197557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2020.105176
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