Loss of CDKL5 in Glutamatergic Neurons Disrupts Hippocampal Microcircuitry and Leads to Memory Impairment in Mice

Cyclin-dependent kinase-like 5 (CDKL5) deficiency is a neurodevelopmental disorder characterized by epileptic seizures, severe intellectual disability, and autistic features. Mice lacking CDKL5 display multiple behavioral abnormalities reminiscent of the disorder, but the cellular origins of these p...

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Udgivet i:J Neurosci
Main Authors: Tang, Sheng, Wang, I-Ting Judy, Yue, Cuiyong, Takano, Hajime, Terzic, Barbara, Pance, Katarina, Lee, Jun Y., Cui, Yue, Coulter, Douglas A., Zhou, Zhaolan
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5546111/
https://ncbi.nlm.nih.gov/pubmed/28674172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0539-17.2017
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