Loss of CDKL5 disrupts kinome profile and event-related potentials leading to autistic-like phenotypes in mice

Mutations in the X-linked cyclin-dependent kinase-like 5 (CDKL5) gene have been identified in neurodevelopmental disorders including atypical Rett syndrome (RTT), autism spectrum disorders (ASDs), and early infantile epileptic encephalopathy. The biological function of CDKL5 and its role in the etio...

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Main Authors: Wang, I-Ting Judy, Allen, Megan, Goffin, Darren, Zhu, Xinjian, Fairless, Andrew H., Brodkin, Edward S., Siegel, Steve J., Marsh, Eric D., Blendy, Julie A., Zhou, Zhaolan
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2012
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3535652/
https://ncbi.nlm.nih.gov/pubmed/23236174
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1216988110
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