Development of CAR T Cells Expressing a Suicide Gene Plus a Chimeric Antigen Receptor Targeting Signaling Lymphocytic-Activation Molecule F7

Chimeric antigen receptors (CARs) are fusion proteins that contain antigen-recognition domains and T cell signaling domains. Signaling lymphocytic-activation molecule F7 (SLAMF7) is a promising target for CAR T cell therapies of the plasma cell malignancy multiple myeloma (MM) because SLAMF7 is expr...

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Publicado en:Mol Ther
Main Authors: Amatya, Christina, Pegues, Melissa A., Lam, Norris, Vanasse, Danielle, Geldres, Claudia, Choi, Stephanie, Hewitt, Stephen M., Feldman, Steven A., Kochenderfer, James N.
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Gene & Cell Therapy 2021
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Original Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7854354/
https://ncbi.nlm.nih.gov/pubmed/33129371
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymthe.2020.10.008
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