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Mitochondrial Protein Adduct and Superoxide Generation are Prerequisites for Early Activation of c-Jun N-terminal Kinase within the Cytosol after an Acetaminophen Overdose in Mice

Acetaminophen (APAP) overdose is the most common cause of acute liver failure in the United States and formation of APAP-protein adducts, mitochondrial oxidant stress and activation of the mitogen activated protein (MAP) kinase c-jun N-terminal kinase (JNK) are critical for APAP-induced cell death....

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Detalhes bibliográficos
Publicado no:Toxicol Lett
Main Authors: Nguyen, Nga T., Du, Kuo, Akakpo, Jephte Y., Umbaugh, David S., Jaeschke, Hartmut, Ramachandran, Anup
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7852579/
https://ncbi.nlm.nih.gov/pubmed/33290831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2020.12.005
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