Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase

Acetaminophen (APAP) overdose is the most common cause of hepatotoxicity and acute liver failure in the United States and many western countries. However, the only clinically approved antidote, N-acetylcysteine, has a limited therapeutic window. 4-Methylpyrazole (4MP) is an antidote for methanol and...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Akakpo, Jephte Y, Ramachandran, Anup, Duan, Luqi, Schaich, Matthew A, Jaeschke, Matthew W, Freudenthal, Bret D, Ding, Wen-Xing, Rumack, Barry H, Jaeschke, Hartmut
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2019
Matèries:
Molecular, Biochemical, and Sytems Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6592188/
https://ncbi.nlm.nih.gov/pubmed/30903181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfz077
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