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MICE DEFICIENT IN PYRUVATE DEHYDROGENASE KINASE 4 ARE PROTECTED AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY

Though mitochondrial oxidant stress plays a critical role in the progression of acetaminophen (APAP) overdose-induced liver damage, the influence of mitochondrial bioenergetics on this is not well characterized. This is important, since lifestyle and diet alter hepatic mitochondrial bioenergetics an...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Toxicol Appl Pharmacol
Prif Awduron: Duan, Luqi, Ramachandran, Anup, Akakpo, Jephte Y., Woolbright, Benjamin L., Zhang, Yuxia, Jaeschke, Hartmut
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6995777/
https://ncbi.nlm.nih.gov/pubmed/31809757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114849
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