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MICE DEFICIENT IN PYRUVATE DEHYDROGENASE KINASE 4 ARE PROTECTED AGAINST ACETAMINOPHEN-INDUCED HEPATOTOXICITY
Though mitochondrial oxidant stress plays a critical role in the progression of acetaminophen (APAP) overdose-induced liver damage, the influence of mitochondrial bioenergetics on this is not well characterized. This is important, since lifestyle and diet alter hepatic mitochondrial bioenergetics an...
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| Veröffentlicht in: | Toxicol Appl Pharmacol |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2019
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6995777/ https://ncbi.nlm.nih.gov/pubmed/31809757 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2019.114849 |
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