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4-Methylpyrazole Protects against Acetaminophen Hepatotoxicity in Mice and in Primary Human Hepatocytes

Liver injury due to acetaminophen (APAP) overdose is the major cause of acute liver failure in the US. While treatment with N-acetylcysteine (NAC) is the current standard of care for APAP overdose, anecdotal evidence suggests that administration of 4-methylpyrazole (4MP) may be beneficial in the cli...

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Detalhes bibliográficos
Publicado no:Hum Exp Toxicol
Main Authors: Akakpo, Jephte Y., Ramachandran, Anup, Kandel, Sylvie E., Ni, Hongmin, Kumer, Sean C., Rumack, Barry H., Jaeschke, Hartmut
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6482816/
https://ncbi.nlm.nih.gov/pubmed/29739258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/0960327118774902
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