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Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice
Acetaminophen (APAP) is a widely used analgesic and is safe at therapeutic doses. However, an overdose of APAP is hepatotoxic and accidental overdoses are increasingly common due to the presence of APAP in several combination medications. Formation of protein adducts (APAP-CYS) are central to APAP-i...
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| Udgivet i: | Arch Toxicol |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2021
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8035234/ https://ncbi.nlm.nih.gov/pubmed/33458793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-02985-6 |
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