Impaired protein adduct removal following repeat administration of subtoxic doses of acetaminophen enhances liver injury in fed mice

Acetaminophen (APAP) is a widely used analgesic and is safe at therapeutic doses. However, an overdose of APAP is hepatotoxic and accidental overdoses are increasingly common due to the presence of APAP in several combination medications. Formation of protein adducts (APAP-CYS) are central to APAP-i...

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Bibliographic Details
Published in:Arch Toxicol
Main Authors: Nguyen, Nga T., Akakpo, Jephte Y., Weemhoff, James L., Ramachandran, Anup, Ding, Wen-Xing, Jaeschke, Hartmut
Format: Artigo
Language:Inglês
Published: 2021
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC8035234/
https://ncbi.nlm.nih.gov/pubmed/33458793
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00204-021-02985-6
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