Role of Extracellular Vesicles in Release of Protein Adducts after Acetaminophen-induced Liver Injury in Mice and Humans

Formation of acetaminophen (APAP) protein adducts are a critical feature of APAP hepatotoxicity, and circulating protein adducts have recently been utilized in bioassays for identification of APAP overdose in humans. Despite their clinical significance, mechanisms of adduct release into the circulat...

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Vydáno v:Toxicol Lett
Hlavní autoři: Duan, Luqi, Ramachandran, Anup, Akakpo, Jephte Y, Weemhoff, James L., Curry, Steven C., Jaeschke, Hartmut
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338225/
https://ncbi.nlm.nih.gov/pubmed/30447259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2018.11.005
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