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Role of Extracellular Vesicles in Release of Protein Adducts after Acetaminophen-induced Liver Injury in Mice and Humans

Formation of acetaminophen (APAP) protein adducts are a critical feature of APAP hepatotoxicity, and circulating protein adducts have recently been utilized in bioassays for identification of APAP overdose in humans. Despite their clinical significance, mechanisms of adduct release into the circulat...

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Bibliographische Detailangaben
Veröffentlicht in:Toxicol Lett
Hauptverfasser: Duan, Luqi, Ramachandran, Anup, Akakpo, Jephte Y, Weemhoff, James L., Curry, Steven C., Jaeschke, Hartmut
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6338225/
https://ncbi.nlm.nih.gov/pubmed/30447259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2018.11.005
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